Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies
Identifieur interne : 000545 ( Main/Exploration ); précédent : 000544; suivant : 000546Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies
Auteurs : Satoshi Fukuyama [Japon] ; Hiroaki Katsura [Japon] ; Dongming Zhao [Japon] ; Makoto Ozawa [Japon] ; Tomomi Ando [Japon] ; Jason E. Shoemaker [Japon] ; Izumi Ishikawa [Japon] ; Shinya Yamada [Japon] ; Gabriele Neumann [États-Unis] ; Shinji Watanabe [Japon] ; Hiroaki Kitano [Japon] ; Yoshihiro Kawaoka [Japon, États-Unis]Source :
- Nature Communications [ 2041-1723 ] ; 2015.
Abstract
Seasonal influenza A viruses cause annual epidemics of respiratory disease; highly pathogenic avian H5N1 and the recently emerged H7N9 viruses cause severe infections in humans, often with fatal outcomes. Although numerous studies have addressed the pathogenicity of influenza viruses, influenza pathogenesis remains incompletely understood. Here we generate influenza viruses expressing fluorescent proteins of different colours (‘Color-flu’ viruses) to facilitate the study of viral infection in
Url:
DOI: 10.1038/ncomms7600
PubMed: 25807527
PubMed Central: 4389232
Affiliations:
- Japon, États-Unis
- Région de Kantō, Wisconsin
- Madison (Wisconsin), Tokyo
- Université de Tokyo, Université du Wisconsin à Madison
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Le document en format XML
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Project, Japan Science and Technology Agency (JST)</institution>, Kawaguchi, Saitama 332-0012,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Katsura, Hiroaki" sort="Katsura, Hiroaki" uniqKey="Katsura H" first="Hiroaki" last="Katsura">Hiroaki Katsura</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Dongming" sort="Zhao, Dongming" uniqKey="Zhao D" first="Dongming" last="Zhao">Dongming Zhao</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST)</institution>, Kawaguchi, Saitama 332-0012,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ozawa, Makoto" sort="Ozawa, Makoto" uniqKey="Ozawa M" first="Makoto" last="Ozawa">Makoto Ozawa</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University</institution>, Kagoshima 890-0065,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Transboundary Animal Distance Center, Joint Faculty of Veterinary Medicine, Kagoshima University</institution>, Kagoshima 890-0065,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ando, Tomomi" sort="Ando, Tomomi" uniqKey="Ando T" first="Tomomi" last="Ando">Tomomi Ando</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST)</institution>, Kawaguchi, Saitama 332-0012,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shoemaker, Jason E" sort="Shoemaker, Jason E" uniqKey="Shoemaker J" first="Jason E." last="Shoemaker">Jason E. Shoemaker</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST)</institution>, Kawaguchi, Saitama 332-0012,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ishikawa, Izumi" sort="Ishikawa, Izumi" uniqKey="Ishikawa I" first="Izumi" last="Ishikawa">Izumi Ishikawa</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Exploratory Research for Advanced 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(JST)</institution>, Kawaguchi, Saitama 332-0012,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Laboratory of Veterinary Microbiology, Department of Veterinary Sciences, University of Miyazaki</institution>, Miyazaki 889-2192,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kitano, Hiroaki" sort="Kitano, Hiroaki" uniqKey="Kitano H" first="Hiroaki" last="Kitano">Hiroaki Kitano</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST)</institution>, Kawaguchi, Saitama 332-0012,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>The Systems Biology Institute</institution>, Minato-ku, Tokyo 108-0071,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Sony Computer Science Laboratories</institution>, Shinagawa-ku, Tokyo 141-0022,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Okinawa Institute of Science and Technology Graduate University</institution>, Onna-son, Okinawa 904-0495,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Exploratory Research for Advanced Technology Infection-Induced Host Responses Project, Japan Science and Technology Agency (JST)</institution>, Kawaguchi, Saitama 332-0012,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName><orgName type="university" n="3">Université de Tokyo</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName><orgName type="university" n="3">Université de Tokyo</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison</institution>, Madison, Wisconsin 53711,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="a10"><institution>Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo</institution>, Minato-ku, Tokyo 108-8639,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName><orgName type="university" n="3">Université de Tokyo</orgName></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Seasonal influenza A viruses cause annual epidemics of respiratory disease; highly pathogenic avian H5N1 and the recently emerged H7N9 viruses cause severe infections in humans, often with fatal outcomes. Although numerous studies have addressed the pathogenicity of influenza viruses, influenza pathogenesis remains incompletely understood. Here we generate influenza viruses expressing fluorescent proteins of different colours (‘Color-flu’ viruses) to facilitate the study of viral infection in <italic>in vivo</italic> models. On adaptation to mice, stable expression of the fluorescent proteins in infected animals allows their detection by different types of microscopy and by flow cytometry. We use this system to analyse the progression of viral spread in mouse lungs, for live imaging of virus-infected cells, and for differential gene expression studies in virus antigen-positive and virus antigen-negative live cells in the lungs of Color-flu-infected mice. Collectively, Color-flu viruses are powerful tools to analyse virus infections at the cellular level <italic>in vivo</italic> to better understand influenza pathogenesis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wright, P F" uniqKey="Wright P">P. F. Wright</name></author><author><name sortKey="Neumann, G" uniqKey="Neumann G">G. Neumann</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T. Watanabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, W C" uniqKey="Yu W">W. C. Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diebold, S S" uniqKey="Diebold S">S. S. Diebold</name></author><author><name sortKey="Kaisho, T" uniqKey="Kaisho T">T. Kaisho</name></author><author><name sortKey="Hemmi, H" uniqKey="Hemmi H">H. Hemmi</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name></author><author><name sortKey="Reis E Sousa, C" uniqKey="Reis E Sousa C">C. Reis e Sousa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pichlmair, A" uniqKey="Pichlmair A">A. Pichlmair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda, K" uniqKey="Honda K">K. Honda</name></author><author><name sortKey="Taniguchi, T" uniqKey="Taniguchi T">T. Taniguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herold, S" uniqKey="Herold S">S. Herold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perrone, L A" uniqKey="Perrone L">L. A. Perrone</name></author><author><name sortKey="Plowden, J K" uniqKey="Plowden J">J. K. Plowden</name></author><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A. Garcia-Sastre</name></author><author><name sortKey="Katz, J M" uniqKey="Katz J">J. M. Katz</name></author><author><name sortKey="Tumpey, T M" uniqKey="Tumpey T">T. M. Tumpey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fukuyama, S" uniqKey="Fukuyama S">S. Fukuyama</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kittel, C" uniqKey="Kittel C">C. Kittel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shinya, K" uniqKey="Shinya K">K. Shinya</name></author><author><name sortKey="Fujii, Y" uniqKey="Fujii Y">Y. Fujii</name></author><author><name sortKey="Ito, H" uniqKey="Ito H">H. Ito</name></author><author><name sortKey="Ito, T" uniqKey="Ito T">T. Ito</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manicassamy, B" uniqKey="Manicassamy B">B. Manicassamy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Helft, J" uniqKey="Helft J">J. Helft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagai, T" uniqKey="Nagai T">T. Nagai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patterson, G" uniqKey="Patterson G">G. Patterson</name></author><author><name sortKey="Day, R N" uniqKey="Day R">R. N. Day</name></author><author><name sortKey="Piston, D" uniqKey="Piston D">D. Piston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaner, N C" uniqKey="Shaner N">N. C. Shaner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Go, J T" uniqKey="Go J">J. T. Go</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, D" uniqKey="Zhao D">D. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salomon, R" uniqKey="Salomon R">R. Salomon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hatta, M" uniqKey="Hatta M">M. Hatta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weissleder, R" uniqKey="Weissleder R">R. Weissleder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jobsis, F F" uniqKey="Jobsis F">F. F. Jobsis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tran, V" uniqKey="Tran V">V. Tran</name></author><author><name sortKey="Moser, L A" uniqKey="Moser L">L. A. Moser</name></author><author><name sortKey="Poole, D S" uniqKey="Poole D">D. S. Poole</name></author><author><name sortKey="Mehle, A" uniqKey="Mehle A">A. Mehle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, W" uniqKey="Pan W">W. Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heaton, N S" uniqKey="Heaton N">N. S. Heaton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghaznavi, F" uniqKey="Ghaznavi F">F. Ghaznavi</name></author><author><name sortKey="Evans, A" uniqKey="Evans A">A. Evans</name></author><author><name sortKey="Madabhushi, A" uniqKey="Madabhushi A">A. Madabhushi</name></author><author><name sortKey="Feldman, M" uniqKey="Feldman M">M. Feldman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scholtissek, C" uniqKey="Scholtissek C">C. Scholtissek</name></author><author><name sortKey="Rohde, W" uniqKey="Rohde W">W. Rohde</name></author><author><name sortKey="Von Hoyningen, V" uniqKey="Von Hoyningen V">V. Von Hoyningen</name></author><author><name sortKey="Rott, R" uniqKey="Rott R">R. Rott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author><author><name sortKey="Krauss, S" uniqKey="Krauss S">S. Krauss</name></author><author><name sortKey="Webster, R G" uniqKey="Webster R">R. G. Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, G J" uniqKey="Smith G">G. J. Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Itoh, Y" uniqKey="Itoh Y">Y. Itoh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gambotto, A" uniqKey="Gambotto A">A. Gambotto</name></author><author><name sortKey="Barratt Boyes, S M" uniqKey="Barratt Boyes S">S. M. Barratt-Boyes</name></author><author><name sortKey="De Jong, M D" uniqKey="De Jong M">M. D. de Jong</name></author><author><name sortKey="Neumann, G" uniqKey="Neumann G">G. Neumann</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W. J. Shieh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Basler, C F" uniqKey="Basler C">C. F. Basler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neumann, G" uniqKey="Neumann G">G. Neumann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smyth, G K" uniqKey="Smyth G">G. K. Smyth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaimal, V" uniqKey="Kaimal V">V. Kaimal</name></author><author><name sortKey="Bardes, E E" uniqKey="Bardes E">E. E. Bardes</name></author><author><name sortKey="Tabar, S C" uniqKey="Tabar S">S. C. Tabar</name></author><author><name sortKey="Jegga, A G" uniqKey="Jegga A">A. G. Jegga</name></author><author><name sortKey="Aronow, B J" uniqKey="Aronow B">B. J. Aronow</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Région de Kantō</li><li>Wisconsin</li></region><settlement><li>Madison (Wisconsin)</li><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li><li>Université du Wisconsin à Madison</li></orgName></list><tree><country name="Japon"><noRegion><name sortKey="Fukuyama, Satoshi" sort="Fukuyama, Satoshi" uniqKey="Fukuyama S" first="Satoshi" last="Fukuyama">Satoshi Fukuyama</name></noRegion><name sortKey="Ando, Tomomi" sort="Ando, Tomomi" uniqKey="Ando T" first="Tomomi" last="Ando">Tomomi Ando</name><name sortKey="Ando, Tomomi" sort="Ando, Tomomi" uniqKey="Ando T" first="Tomomi" last="Ando">Tomomi Ando</name><name sortKey="Fukuyama, Satoshi" sort="Fukuyama, Satoshi" uniqKey="Fukuyama S" first="Satoshi" last="Fukuyama">Satoshi Fukuyama</name><name sortKey="Ishikawa, Izumi" sort="Ishikawa, Izumi" uniqKey="Ishikawa I" first="Izumi" last="Ishikawa">Izumi Ishikawa</name><name sortKey="Ishikawa, Izumi" sort="Ishikawa, Izumi" uniqKey="Ishikawa I" first="Izumi" last="Ishikawa">Izumi Ishikawa</name><name sortKey="Katsura, Hiroaki" sort="Katsura, Hiroaki" uniqKey="Katsura H" first="Hiroaki" last="Katsura">Hiroaki Katsura</name><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><name sortKey="Kitano, Hiroaki" sort="Kitano, Hiroaki" uniqKey="Kitano H" first="Hiroaki" last="Kitano">Hiroaki Kitano</name><name sortKey="Kitano, Hiroaki" sort="Kitano, Hiroaki" uniqKey="Kitano H" first="Hiroaki" last="Kitano">Hiroaki Kitano</name><name sortKey="Kitano, Hiroaki" sort="Kitano, Hiroaki" uniqKey="Kitano H" first="Hiroaki" last="Kitano">Hiroaki Kitano</name><name sortKey="Kitano, Hiroaki" sort="Kitano, Hiroaki" uniqKey="Kitano H" first="Hiroaki" last="Kitano">Hiroaki Kitano</name><name sortKey="Ozawa, Makoto" sort="Ozawa, Makoto" uniqKey="Ozawa M" first="Makoto" last="Ozawa">Makoto Ozawa</name><name sortKey="Ozawa, Makoto" sort="Ozawa, Makoto" uniqKey="Ozawa M" first="Makoto" last="Ozawa">Makoto Ozawa</name><name sortKey="Shoemaker, Jason E" sort="Shoemaker, Jason E" uniqKey="Shoemaker J" first="Jason E." last="Shoemaker">Jason E. Shoemaker</name><name sortKey="Shoemaker, Jason E" sort="Shoemaker, Jason E" uniqKey="Shoemaker J" first="Jason E." last="Shoemaker">Jason E. Shoemaker</name><name sortKey="Watanabe, Shinji" sort="Watanabe, Shinji" uniqKey="Watanabe S" first="Shinji" last="Watanabe">Shinji Watanabe</name><name sortKey="Watanabe, Shinji" sort="Watanabe, Shinji" uniqKey="Watanabe S" first="Shinji" last="Watanabe">Shinji Watanabe</name><name sortKey="Yamada, Shinya" sort="Yamada, Shinya" uniqKey="Yamada S" first="Shinya" last="Yamada">Shinya Yamada</name><name sortKey="Zhao, Dongming" sort="Zhao, Dongming" uniqKey="Zhao D" first="Dongming" last="Zhao">Dongming Zhao</name><name sortKey="Zhao, Dongming" sort="Zhao, Dongming" uniqKey="Zhao D" first="Dongming" last="Zhao">Dongming Zhao</name></country><country name="États-Unis"><noRegion><name sortKey="Neumann, Gabriele" sort="Neumann, Gabriele" uniqKey="Neumann G" first="Gabriele" last="Neumann">Gabriele Neumann</name></noRegion><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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